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Big Dig: Children's Hospital Breaks Ground On Research Center


BOSTON, Feb. 13, 2001 — Children's Hospital Boston broke ground today on a $130-million, 295,000-square foot research facility that will increase its research space by 50 percent.

The 12-story building is being constructed across the street from Children's location in the Longwood Medical Area and is expected to open in the spring of 2003. The new building, combined with the hospital's current Enders Building, will allow for new and expanded laboratories with a particular emphasis on angiogenesis; in vitro tissue engineering of replacement organs; genetics and genomics; neuroscience; and developmental medicine, including adult stem cells. The latter offers the promise of replacing damaged or genetically defective tissues with new ones, since stem cells have the ability to regenerate the tissues they're derived from and can sometimes be persuaded to change their identity and form cells from other tissues.

"Medical research has evolved from a focus on organs to the less specific but powerful molecular level. This requires that we transcend traditional academic department boundaries and look for more interdisciplinary groupings of scientists focused on specific problems," says Sam Lux, M.D., a Children's hematologist/oncologist and researcher who has led the three-year effort to plan the new building. As a current example, Lux points to the Children's Surgical Research Laboratories where oncologists, pathologists, surgeons, cell biologists, and ophthalmologists work side-by-side to study the respective benefits of either halting or promoting angiogenesis (new blood vessel growth).

"With the new research building and updated clinical building, patients and their families will not only benefit from highly personalized care but also from the latest scientific discoveries and state-of-the-art technology."

Children's will locate seven such research groups in the new building and will rent out three floors to other area research groups with complementary interests. The rental floors will generate income to help cover the construction and operating costs of the building. Retail space, including a new restaurant on the first floor, and an additional three floors of parking are also planned.

Later this year, ground will be broken on a building to expand clinical care space, with the demolition of a 5-story building on campus and its replacement with a 10-story building. The new 200,000-square foot clinical care building will provide modernized and expanded space for intensive care, surgical, imaging and emergency services, as well as support growth in patient care. Combined, the two buildings represent a $250 million investment. The hospital will finance the buildings primarily through the issuance of long- term debt. However, $50 million will come from a 5-year philanthropic campaign with a working goal of $200 million.

The hospital has not had a major renovation program for more than a decade, yet during that time inpatient and outpatient visits have grown by 30 percent each. Growth in volume has been accompanied by changes in the overall delivery of care — more intensive, technologically driven and sophisticated inpatient and outpatient care, and tremendous growth in outpatient services.

"With the new research building and updated clinical building, patients and their families will not only benefit from highly personalized care but also from the latest scientific discoveries and state-of-the-art technology. These lab discoveries and the results of clinical trials also advance the health of children around the world," says Bill Boyan, chairman of the Children's Board of Trustees.

Children's Hospital is home to the world's largest pediatric research program, totaling over $100 million in fiscal year 2000 from public and private grants. Research at Children's has driven a history of advances, from the first pediatric remission of leukemia to the promising results of angiogenesis inhibitors in shrinking tumors and tissue engineering in rebuilding defective organs.

As researchers at Children's Hospital become more and more successful in unlocking the mysteries of diseases in children and adults, research space has become a premium. For instance, without any increase in space, total research funding has increased by 52 percent in the past five years. Currently, Children's Hospital has more grant dollars per square-foot than any other research enterprise in Boston, creating crowding at a time when sophisticated equipment is putting even more demand on space. In addition, the National Institutes of Health is projected to increase its funding by 30 percent by 2004.

"We absolutely need the now space to recruit and retain top researchers. We are incredibly fortunate to have a high-concentration of nationally recognized scientists, including six members of the National Academy of Science and nine Howard Hughes Medical Institute investigators, who are committed to mentoring the next generation of researchers to carry on their work," says Dr. James Mandell, president and chief executive officer of Children's.

Source: Children's Hospital Boston




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